1. (人や物を)…と判断する
After his adventures, when he returned to his planet to live, people did not know what to make of him.(彼が冒険を終えて、自分が住む惑星に帰ってきたとき、人々は彼をどう扱ってよいか計りかねていた。)
What do you make of the idea of God as employer?(神を雇い主とみなす考え方についてどう思いますか？)
2. 上手くやる
Do you want to make something of yourself and get ahead?(一人前になって成功したいですか？)